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Lecturer(s)
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Pavelka Jaroslav, Mgr. Ph.D.
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Course content
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1. Chemical composition of the cell, biopolymers, chaperons, genomics, proteomics, glycomics. 2. Genome and its structure. Comparison of prokaryotes, eukaryotes and arches. Methods of study of genomes. 3. Sequential sequences and transposons. Results of sequencing of the human genome. 4. Structure of chromosomes, cytogenetic methods and their significance, methods FISH, QF PCR their importance for clinical genetics. 5. The central dogma of molecular biology. The course of replication. 6. Course of transcription, post-communicative modification. Regulation of gene expression in prokaryotes and eukaryotes. 7. Course of translation, post-translational adaptations and their meaning. 8. Cytoplasmic membrane and its function, membrane transport. Electrical properties of cell membranes. 9. Membrane principle of cell organization, biogenesis and function of individual organelles, transport of vesicles. 10. Cytoskeletal principle of cell organization, components of cytoskeleton and their function. 11. Movement of cell structures, molecular motors, cell movement. 12. Intercellular interactions, interactions of cells with intercellular mass. Extracellular matrix. 13. Intercellular signaling, hormones and receptors. Credit test.
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Learning activities and teaching methods
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Lecture with visual aids
- Contact hours
- 26 hours per semester
- Preparation for an examination (30-60)
- 30 hours per semester
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| prerequisite |
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| Knowledge |
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| to know the basic study of molecular and cell biology at the level of bachelor study of biology to know the basics of replication, transcription, translation and their regulation Know the types of distribution and cause of mutations to know the basics of DNA transposition to know the basic methods of molecular biology to know the basic science of genetics at the level of bachelor study of biology |
| Skills |
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| use the knowledge of a bachelor's degree program, or supplement the curriculum at this level analytically linking facts into a meaningful whole |
| Competences |
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| N/A |
| N/A |
| learning outcomes |
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| Knowledge |
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| Know the chemical composition of the cell, biopolymers, chaperons, genomics To know the genome and its structure To know the methods of studying genomes To know repetitive sequences and transposons To know the cytoskeletal principle of the cell organization, the components of the cytoskeleton and their function Know intercellular signaling, hormones and receptors |
| Skills |
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| He knows the construction of prokaryotic and eukaryotic cells, knows the basic methods of studying the genome understands the function of the cytoplasmic membrane in cells understands the connectivity of the living system at the molecular and organ level |
| Competences |
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| N/A |
| teaching methods |
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| Knowledge |
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| Lecture with visual aids |
| Skills |
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| Lecture |
| Competences |
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| Lecture |
| assessment methods |
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| Knowledge |
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| Written exam |
| Skills |
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| Written exam |
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Recommended literature
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Alberts, B. a kol. Základy buněčné biologie : úvod do molekulární biologie buňky. Ústí nad Labem: Espero Publishing, 1998. ISBN 80-902906-2-0.
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Bresler, Semen Jefimovič. Molekulární biologie. Praha : Academia, 1979.
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De Duve, Ch. A Guided Tour of the Living Cell. University Press, 1985.
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Karlson, Peter. Základy biochemie. Praha : Academia, 1981.
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Kubišta, V. Buněčné základy životních dějů. Praha, 1998.
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Kubišta, V. Obecná biologie. Fortuna Praha, 2000.
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Romanovský, A. Obecná biologie : celost. vysokošk. učebnice pro stud. přírodověd. a pedagog. fakult. Praha : SPN, 1985.
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Rosypal, S. a kol. Nový přehled biologie. Praha, 2003.
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Rosypal, Stanislav. Přehled biologie. Praha : Scientia, 1994. ISBN 80-85827-32-8.
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Rosypal, Stanislav. Úvod do molekulární biologie. 2.,rozš. vyd. Brno : Stanislav Rosypal, 1997.
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Vlasák. Molekulární biologie.. Biologická fakulta JCU, 1998.
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Vodrážka, Zdeněk. Biochemie. Praha : Academia, 1996. ISBN 80-200-0600-1.
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Vonka, Z. a kol. Kapitoly molekulové biologie. H&H Praha, 1992.
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Žurovec, J. Molekulární biologie živočichů. Biologická fakulta JCU, 1999.
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