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Lecturer(s)
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Vimmerová Hana, Mgr.
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Kukrálová Simona, Mgr.
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Cibulka Roman, MUDr. Ph.D., MBA
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Brož Pavel, MUDr. Ph.D.
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Bršlicová Kateřina, Ing.
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Prokop Pavel, RNDr. DiS.
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Course content
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Lectures 1. Laboratory examination for diabetes. Diagnosis of diabetes, determination of glucose, glycated hemoglobin, albuminuria. Complications of diabetes. Diabetes and pregnancy, other causes of hypo- and hyperglycemia. 2. Laboratory examination for liver disease. Differential diagnosis of hyperbilirubinemia. 3. Laboratory signs of malignant neoplasm. 4. Clinical-biochemical examination of the digestive tract. Parenteral and enteral nutrition from the point of view of clinical biochemistry. Investigation and monitoring of nutritional status. Malnourished. Obesity. 5. Laboratory examination during pregnancy. Adaptation reaction of the body to pregnancy, changes in physiological ranges laboratory tests in pregnancy, diagnostic use of laboratory examination in pregnancy. Peculiarities laboratory investigation in childhood and old age. 6. Cerebrospinal fluid examination. 7. Hormones. General information on metabolism and determination of hormones, hypothalamic and pituitary hormones, thyroid hormones glands, adrenal cortex, sex hormones, tissue hormones. 8. Trace elements. Iron (Fe), copper (Cu), zinc (Zn), selenium (Se) and other trace elements. Vitamins. 9. - 11. Modern trends in clinical biochemistry. Automation and integration of the laboratory process, consolidation of laboratories, centralization and POCT, the concept of evidence-based medicine, personalized medicine. Certification and accreditation laboratories, correct laboratory work. A Lab exercise 1. - 4. Laboratory examination for kidney disease, functional tests including calculations. 5. - 8. Hereditary disorders of metabolism. 9. - 11. Functional tests in clinical biochemistry.
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Learning activities and teaching methods
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- Contact hours
- 77 hours per semester
- Preparation for laboratory testing; outcome analysis (1-8)
- 5 hours per semester
- Preparation for comprehensive test (10-40)
- 15 hours per semester
- Preparation for an examination (30-60)
- 40 hours per semester
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| prerequisite |
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| Knowledge |
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| to explain the meaning of reference values and decision limits, the meaning of analytical and clinical properties of laboratory methods and their use in laboratory medicine |
| to define the difference between laboratory test reference values and decision limits |
| Skills |
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| to distinguish between diagnostic sensitivity and specificity |
| to compare measured values with reference values |
| to perform basic calculations in the clinical laboratory (pH, buffers, concentration of solutions) |
| Competences |
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| N/A |
| N/A |
| learning outcomes |
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| Knowledge |
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| will explain the principles of laboratory examination in DM, kidney disease, in gastroenterology, in liver and biliary tract diseases |
| characterizes the specifics of laboratory examinations in pregnancy, childhood and old age |
| explains the principle of determining hormones and interprets its meaning |
| characterizes cytochemical examination of cerebrospinal fluid |
| characterizes the possibilities of laboratory diagnosis of hereditary metabolic disorders |
| Skills |
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| independently performs functional tests in clinical biochemistry |
| keeps protocols and controls instrumentation in the clinical biochemistry laboratory |
| Competences |
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| N/A |
| N/A |
| N/A |
| teaching methods |
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| Knowledge |
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| Lecture |
| Skills |
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| Laboratory work |
| Competences |
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| Lecture |
| Laboratory work |
| assessment methods |
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| Knowledge |
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| Oral exam |
| Test |
| Skills |
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| Skills demonstration during practicum |
| Competences |
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| Oral exam |
| Skills demonstration during practicum |
| Test |
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Recommended literature
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CIBULKA, Roman. Stopové prvky..
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DASTYCH, Milan, BREINEK, Petr a kol. Klinická biochemie: bakalářský obor Zdravotní laborant. 3. vydání, 1. dotisk. Brno: Masarykova univerzita, 2021. ISBN 978-80-210-7788-1.
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RACEK, Jaroslav. Funkční zkoušky ledvin..
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RACEK, Jaroslav. Hormony..
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RACEK, Jaroslav. Laboratorní vyšetření u onemocnění trávicího traktu..
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RACEK, Jaroslav, RAJDL, Daniel et al. Klinická biochemie. Třetí, přepracované a rozšířené vydání.. Praha : Galén, 2021. ISBN 978-80-7492-545-0.
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RACEK, Jaroslav. Trendy v laboratorní medicíně..
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ZIMA, Tomáš. Laboratorní diagnostika. Třetí, doplněné a přepracované vydání.. Praha: Galén, 2013. ISBN 978-80-7492-062-2.
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