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Lecturer(s)
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Jaklová Radka, MUDr.
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Polendová Daniela, MUDr.
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Course content
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History of genetics and its division. Cell cycle and mitosis. Meiosis. Gametogenesis in men and women. Structure and function of deoxyribonucleic acid. Gene and the transfer of genetic information. Mendel's laws. Basic terms: genotype, phenotype, dominance, recessivity, homozygote, heterozygot, types of inheritance. Pedigree analysis. Karyotype, the structure of chromosome. Examination methods in cytogenetics. Origin and types of chromosomal aberrations, numerical chromosomal aberrations, structural chromosomal aberrations. Down, Edwards, Patau, cat cry, Klinefert, XYY and Turner syndroms. Prenatal diagnostics possibilities. Examination methods in molecular genetics. The genetic engineering and the possibilities of therapy of hereditary diseases. Genetic counseling. Prenatal diagnostics and genetics. Hereditary metabolic disorders in humans, treatment options and the register. The effect of mutagenic environmental factors and testing options. Ecogenetics. Pharmacogenetics. Immunogenetics. Population genetics. Genetics and Society. The process of carcinogenesis-types of mutations in selected types of malignancies.
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Learning activities and teaching methods
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Lecture supplemented with a discussion, Multimedia supported teaching
- Contact hours
- 8 hours per semester
- Preparation for comprehensive test (10-40)
- 15 hours per semester
- Preparation for an examination (30-60)
- 30 hours per semester
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| prerequisite |
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| Knowledge |
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| No particular prerequisites specified. |
| learning outcomes |
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| The students will know basic laws of genetics. They will be able to recognize genetically conditioned diseases and disorders. They will be able to choose appropriate cytogenetical and molecular-genetical investigation methods. |
| teaching methods |
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| Lecture supplemented with a discussion |
| Multimedia supported teaching |
| assessment methods |
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| Oral exam |
| Test |
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Recommended literature
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Michalová, K. Úvod do lidské cytogenetiky. Brno, 1999.
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Pritchard, D. - Korf, B. Základy lékařské genetiky. Praha: Galén,, 2007.
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Snustad, D. - Simmons, M. Genetika. Brno: Nakladatelství Masarykovy univerzity, 2009.
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Thomson and Thomson. Klinická genetika, 6. vydání. 2004. ISBN 80-7254-475-6.
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