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Lecturer(s)
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Richtr Václav, Doc. Mgr. CSc.
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Hrdlička Jan, Ing. Ph.D.
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Course content
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1st-2nd lecture Biochemical markers of poisonings. The main discipline of toxicology. Entering channel of nox into the organism, the possibilities of prevention. Therapeutic extensity, toleration, poison addictiveness. The main kinetic parameters of metabolism and poison excretion, compartmen meaning; the dependence of the effects upon dose and concentration of poison. The main types of nox target effects on the organism. Median lethal dose, minimum lethal dose, maximum permissible concentrations, acceptable daily dose of poison, cumulation coefficient. QSAR. 3rd lecture Standard methods of toxicity testing and substance mutagenicity. Biological exposure tests. Two phases of biotransformation. 4th lecture Health harmfulness of the elements C, Si, Pb, nitrogen compound. Health harmfulness of P, As, Sb, Bi. 5th lecture Health harmfulness of oxygen, free oxygen radicals and peroxides. 6th lecture Health harmfulness of sulfur and selenium. Toxicology of fluorine, chlorine, bromine, jodine and their compounds. 7th lecture Health harmfulness of copper and silver. Toxicology of zinc, cadmium, mercury, chromium, manganese, cobalt, iron, nickel. 8th lecture Health harmfulness and dangerousness of aliphatic hydrocarbons. Health harmfulness and danderousness of aromatic hydrocarbons. 9th lecture Toxicity of ethanol and methanol. Toxicology of glycol, phenols, cresols. 10th lecture Toxicity of aliphatic halogenated hydrocarbons, nitro-, amino- and hydrazine derivatives of hydrocarbons. Health harmfulness of aldehydes and ketones. Toxicology of esters of inorganic and organic acids. 11th lecture Toxicologal charakteristics of radioactive substances. Definition of poisons, corrosive substances, narcotic and psychotropic substances; the principles of gaining and storage of poisons. 12th The principles of work with poisons. Definition and classification of combustible. The principles of giving first aid for chemical poisoning. First aid for chemical burns and burns, for eye injury.
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Learning activities and teaching methods
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Self-study of literature, Lecture
- Contact hours
- 8 hours per semester
- Preparation for an examination (30-60)
- 20 hours per semester
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| prerequisite |
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| Knowledge |
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| characterize basic metabolic processes |
| characterize types of chemical reactions |
| characterize individual types of chemical compounds |
| Skills |
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| to evaluate the qualitative and quantitative composition of the studied systems |
| to work with available literature and electronic resources |
| learning outcomes |
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| Knowledge |
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| explain the toxicity of individual elements and chemical compounds |
| to classify products of human activity on the basis of knowledge of the toxicological properties of the substances |
| Skills |
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| to assess the hazards of toxic substances for human behavior and development |
| apply theoretical knowledge from the field of toxicology to practice |
| teaching methods |
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| Knowledge |
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| Lecture |
| Self-study of literature |
| assessment methods |
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| Combined exam |
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Recommended literature
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HAMPL, F., RÁDL, S., PALEČEK, J. Farmakochemie. VŠCHT, Praha, 2015. ISBN 978-80-7080-875-7.
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Horák, Josef. Ekologická rizika spojená s výrobou a použitím chemických látek a ochrana proti nim. Ostrava : Vysoká škola báňská - Technická univerzita Ostrava, 1996. ISBN 80-7078-369-9.
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Jílek, T. Vybrané kapitoly z toxikologie I, II. Plzeň, 1998.
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KOČÍ, V., MOCOVÁ, K. Ekotoxikologie pro chemiky. VŠCHT, Praha, 2009. ISBN 978-80-7080-699-9.
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Kvasničková E. Xenobiochemie. UK Praha, 1996.
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LINHART I. Toxikologie: Interakce škodlivých látek s živými organismy, jejich mechanismy, projevy a důsledky. VŠCHT, Praha, 2014. ISBN 978-80-7080-877-1.
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LINHART I. Základní pojmy v toxikologii, ekologii a ekotoxikologii. Basic Terms in Toxicology, Ecology and Ecotoxicology. VŠCHT, Praha, 2019. ISBN 978-80-7592-040-9.
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Prokeš J. a kol. Základy toxikologie I. a II.. Karolinum Praha, 1997.
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Tichý, Miloň. Toxikologie pro chemiky : toxikologie obecná, speciální, analytická a legislativa. 1. vyd. Praha : Karolinum, 1998. ISBN 80-7184-625-2.
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