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Main menu for Browse IS/STAG
Course info
KAZ / ZGL
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Course description
Department/Unit / Abbreviation
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KAZ
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ZGL
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Academic Year
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2023/2024
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Academic Year
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2023/2024
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Title
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Basics of Genetics
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Form of course completion
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Exam
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Form of course completion
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Exam
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Accredited / Credits
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Yes,
2
Cred.
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Type of completion
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Combined
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Type of completion
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Combined
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Time requirements
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Lecture
2
[Hours/Week]
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Course credit prior to examination
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Yes
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Course credit prior to examination
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Yes
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Automatic acceptance of credit before examination
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Yes in the case of a previous evaluation 4 nebo nic.
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Included in study average
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YES
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Language of instruction
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Czech
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Occ/max
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Automatic acceptance of credit before examination
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Yes in the case of a previous evaluation 4 nebo nic.
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Summer semester
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31 / -
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0 / -
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0 / -
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Included in study average
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YES
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Winter semester
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0 / -
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0 / -
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0 / -
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Repeated registration
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NO
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Repeated registration
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NO
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Timetable
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Yes
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Semester taught
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Summer semester
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Semester taught
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Summer semester
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Minimum (B + C) students
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10
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Optional course |
Yes
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Optional course
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Yes
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Language of instruction
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Czech
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Internship duration
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0
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No. of hours of on-premise lessons |
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Evaluation scale |
1|2|3|4 |
Periodicity |
každý rok
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Evaluation scale for credit before examination |
S|N |
Periodicita upřesnění |
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Fundamental theoretical course |
Yes
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Fundamental course |
No
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Fundamental theoretical course |
Yes
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Evaluation scale |
1|2|3|4 |
Evaluation scale for credit before examination |
S|N |
Substituted course
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KTB/ZGL
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Preclusive courses
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N/A
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Prerequisite courses
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N/A
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Informally recommended courses
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N/A
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Courses depending on this Course
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N/A
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Histogram of students' grades over the years:
Graphic PNG
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XLS
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Course objectives:
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A course is aimed at explanation of basic rules and principles of heredity and changeability. These rules are connected with current knowledge of a genom. Conclusion necessary for application in the field of genetics results from this knowledge.
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Requirements on student
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credit test
oral exam
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Content
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Lectures: 1. History of genetics in connection to current knowledge: J. G. Mendel, dhereditary; T. H. Morgan chromosomes; O. Avery DNA; J. Watson, F. Crick structure of DNA; J. Monod operon; project of mapping of a human genome. 2. Biopolymers, structure of DNA, gene structure, genetic code, genetic information:definition of a gene, transfer of genetic information (DNA replication), types of mutations. 3. Expression of genetic information, transcription, translation, transcription factors. 4. Cell cycle, mitosis, meiosis. 5. Genotype, fenotype, allele, homozygote, heterozygote. 6. Genetic disease, hereditary disposition, individual hereditary diseases - autosomal, gonosomal, nomenclature, examples. 7. Basics of cytogenetics, structure of human chromosomes, human caryotype, normal and aberrant caryotype, congenital chromosomal aberrations, oncocytogenetics. 8. Linkage of genes, types of inheritance, Mendel's laws, heritability, expressivity,penetrance, gene binding, map, association of characters. 9. Individual genetic variation, polymorphisms, their use in medical genetics. 10. Variability and methods of assessment. 11. Genetic variability of population, phenotypes, genotypes and gene frequencies, Hardy- Weinberg law. 12.. Monogenic hereditary disease, molecular and biochemical principles. 13. Polygenic inheritance and multifactoral congenital defects. 14. Genetics and malignant diseases (tumors). 15. Research: genealogic, gemellilogic, population.
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Activities
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Fields of study
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Guarantors and lecturers
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Literature
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-
Basic:
KOHOUTOVÁ, Milada a kol. Lékařská biologie a genetika II. díl. 2. vydání.. Praha: Karolinum, 2017. ISBN 978-80-246-3790-7.
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Basic:
PANCZAK Aleš a Berta OTOVÁ. Lékařská biologie a genetika (III. díl).. Praha: Karolinum, 2020. ISBN 978-80-246-4452-3.
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Basic:
OTOVÁ, Berta, Romana MIHALOVÁ A Klára BOBKOVÁ. Základy biologie a genetiky člověka. Vydání druhé.. Praha: Karolinum, 2020. ISBN 978-80-246-4565-0.
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Recommended:
SNUSTAD, D. Peter a Michael J. SIMMONS. Genetika. Druhé, aktualizované vydání. RELICHOVÁ, Jiřina (ed.). Brno: Masarykova univerzita, 2017. ISBN 978-80-210-8613-5.
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Recommended:
NUSSBAUM, Robert L., Roderick R. MCINNES, Huntington F. WILLARD, James THOMPSON a Margaret Wilson THOMPSON. Klinická genetika. Thompson & Thompson : 6. vyd.. Praha: Triton, 2004. ISBN 80-7254-475-6.
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On-line library catalogues
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Time requirements
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Full-time form of study
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Activities
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Time requirements for activity [h]
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Contact hours
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30
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Preparation for an examination (30-60)
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20
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Preparation for comprehensive test (10-40)
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8
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Total
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58
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Prerequisites
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Knowledge - students are expected to possess the following knowledge before the course commences to finish it successfully: |
to describe cell organelles at the cellular and subcellular level |
Skills - students are expected to possess the following skills before the course commences to finish it successfully: |
to master the basic terminology of cellular and molecular biology |
Competences - students are expected to possess the following competences before the course commences to finish it successfully: |
N/A |
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Learning outcomes
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Knowledge - knowledge resulting from the course: |
explains the basic laws of heredity and variability and relates these laws to current knowledge of the genome and its functioning |
describes in detail the transmission of genetic information at the molecular and cellular level, as well as at the individual and population level |
Skills - skills resulting from the course: |
draws conclusions for application in the field of clinical genetics |
interprets pathological processes and structures manifested by hereditary diseases |
Competences - competences resulting from the course: |
N/A |
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Assessment methods
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Knowledge - knowledge achieved by taking this course are verified by the following means: |
Oral exam |
Test |
Skills - skills achieved by taking this course are verified by the following means: |
Oral exam |
Competences - competence achieved by taking this course are verified by the following means: |
Oral exam |
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Teaching methods
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Knowledge - the following training methods are used to achieve the required knowledge: |
Lecture supplemented with a discussion |
Skills - the following training methods are used to achieve the required skills: |
Seminar |
Competences - the following training methods are used to achieve the required competences: |
Lecture supplemented with a discussion |
Seminar |
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